Which drug is known to require a higher dose when administered via ETT compared to IV?

Epinephrine is known to require a higher dose when administered via the endotracheal tube (ETT) compared to intravenous (IV) administration. This is due to the fact that when delivered through the ETT, epinephrine is less efficiently absorbed into the systemic circulation. Consequently, a higher dosage is necessary to achieve the desired therapeutic effect in a critical situation like cardiac arrest.

In pediatric advanced life support, it's vital to ensure that medications are given in sufficient doses to be effective, especially when traditional routes (like IV access) are not available. This difference in dosing between the routes underscores the importance of understanding pharmacokinetics in emergent pediatric care.